AVT (Shanghai) Pharmaceutical Tech Co., Ltd.
dc chol

DC-CHOL

DC-CHOL is an effective steroid-based transfection agent and lipid formulation reagent. It is primarily employed in the preparation of various carriers, including microbubbles for contrast ultrasound imaging, liposomes, and precursor liposome precursors for liposomal glutathione (L-GSH).


PRODUCT DESCRIPTION

Product NameDC-CHOL
Chemical Name3β- [N- (N, N-dimethylaminoethane) carbamoyl] cholesterol hydrochloride
CAS No.

166023-21-8

NMPA CDE registration no./
USFDA DMF No./
Quality gradeReagent 
Quality standardsManufacturer's standard
Molecular Formula

C32H57N2O2Cl

Applications and examples

Sterol-based transfection agents: DC-Chol/DOPE, a low-toxicity, high-efficiency nucleic acid transfection combination, typically in ratios of 1:1 or 3:1.Cationic lipid microbubble contrast agents: Novel cationic ultrasound contrast agents prepared using DC-Chol can efficiently encapsulate genes and significantly enhance in vivo imaging capabilities.

Product codeO02003
Package sizes1g
Storage condition

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)


Key Benefits of DC-CHOL

Compared to other cationic lipids such as DOTMA or DOTAP, liposomes prepared from DC-Chol and DOPE (at a ratio of 1:1, molar/molar) exhibit only 50% of nanoparticles carrying charge at pH 7. This renders DC-Chol/DOPE liposomes more prone to dissociation compared to DOTAP/DOPE and DOTAM/DOPE liposomes, demonstrating faster mRNA delivery and enhanced cellular transfection efficiency.


DC-CHOL Product Properties

DC-CHOL is a derivative of cholesterol, synthesized through a chemical reaction between dimethylamine and cholesterol. The aminoethylglycine ester formed during its synthesis possesses degradability. It is a commonly used cationic lipid for preparing lipid nanoparticles (LNPs), providing LNPs with positive charge and stabilizing their membrane structure.


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