AVT (Shanghai) Pharmaceutical Tech Co., Ltd.
12 dioleoyl sn glycero 3 phosphoethanolamine dope


As a commonly used helper lipid, DOPE exhibits strong synergistic effects in the preparation of cationic liposomes. Liposomes formulated with DOPE have been developed into commercial transfection reagents and are widely used in basic research. Additionally, DOPE is also an essential helper lipid in cationic lipid formulations and marketed liposomal vaccines such as Epaxal and Inflexal V. 

NMPA CDE registration no.: /USFDA
DMF no.: 028884


Product nameDOPE
Chemical name1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
CAS No.4004-05-1
FDA DMF Number028884
Quality standardsmanufacturer's standard
Molecular formulaC41H78NO8P
Content determination≧98%
Molecular weight744.0
Product CodeS03005
Available Package Sizes1g; 10g; 50g


DOPE is the most commonly used helper lipid. Liposomes prepared using DOPE demonstrate better fusogenicity and transfection efficiency compared to those prepared using DOPC or CHO. DOPE can facilitate self-assembly and endosomal escape of liposomes. When combined with cationic lipids, DOPE can enhance the transfection efficiency of naked siRNA.


DOPE is a phosphatidylethanolamine with two unsaturated chains (C18). The unsaturated tails facilitate the formation of more fluid lipid bilayers and can also adopt a hexagonal (HII) phase. The HII phase aids in promoting fusion between lipid bilayers and intracellular membranes, facilitating the release of nucleic acids into the cytoplasm.

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