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DC-CHOL is an effective steroid-based transfection agent and lipid formulation reagent. It is primarily employed in the preparation of various carriers, including microbubbles for contrast ultrasound imaging, liposomes, and precursor liposome precursors for liposomal glutathione (L-GSH).
| Product name | DC-CHOL |
| Chemical name | 3β- [N- (N, N-dimethylaminoethane) carbamoyl] cholesterol hydrochloride |
| Molecular formula | C32H57N2O2Cl |
| CAS No. | 166023-21-8 |
| CDE Record registration Number | |
| FDA DMF Number | |
| Grade | reagent |
| Quality standards | |
| Sufficient supply, cost-effective | |
| Description | White or almost white powder |
| Applications | Cationic lipid microbubble ultrasonic contrast agent |
| Product Code | O02003 |
| Available Package Sizes |
Compared to other cationic lipids such as DOTMA or DOTAP, liposomes prepared from DC-Chol and DOPE (at a ratio of 1:1, molar/molar) exhibit only 50% of nanoparticles carrying charge at pH 7. This renders DC-Chol/DOPE liposomes more prone to dissociation compared to DOTAP/DOPE and DOTAM/DOPE liposomes, demonstrating faster mRNA delivery and enhanced cellular transfection efficiency.
DC-CHOL is a derivative of cholesterol, synthesized through a chemical reaction between dimethylamine and cholesterol. The aminoethylglycine ester formed during its synthesis possesses degradability. It is a commonly used cationic lipid for preparing lipid nanoparticles (LNPs), providing LNPs with positive charge and stabilizing their membrane structure.
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