AVT (Shanghai) Pharmaceutical Tech Co., Ltd.
cho

Cholesterol (plant origin)

The high-purity cholesterol (CHO) supplied by V.A.T. is suitable for the preparation of fat emulsions and liposomes. Compared to its role as an emulsifier in fat emulsions, CHO is more widely used in liposome preparation. It has been extensively employed as a membrane material in commercially available liposomal products and liposomal products (such as Lipoplatin, a liposomal cisplatin) at clinical stages.


PRODUCT DESCRIPTION

Product Name

CHO(plant origin)

Chemical Name/
CAS No.

57-88-5

NMPA CDE registration no./
USFDA DMF No./
Quality gradeInjection
Quality standardsManufacturer's standard
Molecular FormulaC27H46O
Applications and examples

CHO-HP (plant-derived) is high-purity cholesterol used in formulations of emulsions,

liposomes, and lipid nanoparticles (LNPs). Compared to its use as an emulsifier for 

lipid emulsions, it has a broader application in the field of liposomes. 

Product codeB03001
Package sizes5g, 10g, 50g
Storage condition

This product should be stored and transported in a sealed and light-protected container

 at controlled room temperature. Retest annually when stored properly. 


Advantages of  CHO(plant origin)

CHO can insert into the phospholipid bilayer of liposomes, interacting with phospholipid molecules to modulate the fluidity of the liposome membrane. Its effect varies with temperature changes;

As CHO is amphiphilic, possessing both hydrophilic and hydrophobic properties, it can enhance the stability of liposomes by regulating the liposome membrane. 


CHO(plant origin) Product Properties

Traditional liposomes are primarily composed of phospholipids and cholesterol. Being a key component of the liposomal bilayer, CHO presents in almost all marketed products (refer to Table 1). In Shingrix (Zoster Vaccine Recombinant, Adjuvanted), CHO is used in a 2:1 ratio (CHO:QS21, w/w) to prevent the hydrolysis of the immune-enhancing agent QS21 in the adjuvant AS01B. In AmBisome (Amphotericin B liposome), CHO maintains the stability of the liposome in the bloodstream, preventing drug leakage while also reducing the toxicity of the liposomal formulation. 

CHO(plant origin)Product Properties

Cholesterol, also known as cholestane, is a cyclopentane polyhydrophenanthrene derivative. At temperatures above the phase transition temperature, CHO reduces the mobility of phospholipid fatty acid chains, thereby decreasing the fluidity of phospholipid molecules. Conversely, at temperatures below the phase transition temperature, it prevents the interaction between phospholipid fatty acid chains, thereby preventing a significant decrease in the fluidity. 

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