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ALC-0159 cas: 1849616-42-7 is a polyethylene glycol (PEG)-lipid conjugate also called a PEGylated lipid which has been used to form lipid nanoparticles (LNPs) for delivery of RNA. According to public information, ALC0159 is one of the excipients of Pfizer's COVID-19 mRNA vaccine (Comirnaty®). ALC-0159 is a non-ionic surfactant by its nature. It allows forming a hydrophilic layer that enhancing the stabilizes of the nanosystem in polar solvent, contributing to storage stability and reducing non-specific binding to proteins.
This is a reagent grade product, for research use only. Additional information can be found here.
| Product name | ALC-0159 |
| Chemical name | 2-[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide |
| CAS No. | 1849616-42-7 |
| Grade | Injection |
| Quality standards | manufacturer's standard |
| Molecular formula | C31H63NO2(C2H4O)n, n≈45 |
| Content determination | ≧97% |
| Molecular weight | 2464.2 |
| Product Code | O02009 |
| Available Package Sizes | 1g |
What is lipid ALC0159? ALC-0159 is an excipient, which refers to a specialized PEG/lipid conjugate (i.e. PEGylated lipid) that is utilized in the Comirnaty® vaccines. It consists of a PEG moiety that has a mass of 2 kilodaltons and a lipid moiety. LNPs are the current state-of-the-art mRNA delivery systems and typically consist of varying ratios of cholesterol, helper lipid, ionizable lipid and polyethylene glycol (PEG)-lipid. Different from common inert excipients, PEG-lipid plays an important role in LNPs and affects various properties of LNP particles, including LNP particle size and transfection efficiency, etc.
Pfizer/Biotechnology COVID-19 vaccine Comirnaty uses ALC0159 to improve the effectiveness of the vaccine.
ALC-0159, whose chemical identifier is 1849616-42-7, is a PEGylated lipid, specifically, ALC0159 is the N, N-dimyristylamide of 2-hydroxyacetic acid, O-pegylated to a PEG chain mass of about 2 kilodaltons. ALC0159 is a non-ionic surfactant by its nature. ALC0159 has been deployed in the Pfizer-BioNTech SARS-CoV-2 mRNA vaccine.
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