|Chemical name||2-[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide|
|Quality standards||manufacturer's standard|
|Molecular formula||C31H63NO2(C2H4O)n, n≈45|
|Available Package Sizes||1g|
What is lipid ALC0159? ALC-0159 is an excipient, which refers to a specialized PEG/lipid conjugate (i.e. PEGylated lipid) that is utilized in the Comirnaty® vaccines. It consists of a PEG moiety that has a mass of 2 kilodaltons and a lipid moiety. LNPs are the current state-of-the-art mRNA delivery systems and typically consist of varying ratios of cholesterol, helper lipid, ionizable lipid and polyethylene glycol (PEG)-lipid. Different from common inert excipients, PEG-lipid plays an important role in LNPs and affects various properties of LNP particles, including LNP particle size and transfection efficiency, etc.
Pfizer/Biotechnology COVID-19 vaccine Comirnaty uses ALC0159 to improve the effectiveness of the vaccine.
ALC-0159, whose chemical identifier is 1849616-42-7, is a PEGylated lipid, specifically, ALC0159 is the N, N-dimyristylamide of 2-hydroxyacetic acid, O-pegylated to a PEG chain mass of about 2 kilodaltons. ALC0159 is a non-ionic surfactant by its nature. ALC0159 has been deployed in the Pfizer-BioNTech SARS-CoV-2 mRNA vaccine.
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