Product name | ALC-0159 |
Chemical name | 2-[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide |
CAS No. | 1849616-42-7 |
Grade | Injection |
Quality standards | manufacturer's standard |
Molecular formula | C31H63NO2(C2H4O)n, n≈45 |
Content determination | ≧97% |
Molecular weight | 2464.2 |
Product Code | O02009 |
Available Package Sizes | 1g |
What is lipid ALC0159? ALC-0159 is an excipient, which refers to a specialized PEG/lipid conjugate (i.e. PEGylated lipid) that is utilized in the Comirnaty® vaccines. It consists of a PEG moiety that has a mass of 2 kilodaltons and a lipid moiety. LNPs are the current state-of-the-art mRNA delivery systems and typically consist of varying ratios of cholesterol, helper lipid, ionizable lipid and polyethylene glycol (PEG)-lipid. Different from common inert excipients, PEG-lipid plays an important role in LNPs and affects various properties of LNP particles, including LNP particle size and transfection efficiency, etc.
Pfizer/Biotechnology COVID-19 vaccine Comirnaty uses ALC0159 to improve the effectiveness of the vaccine.
ALC-0159, whose chemical identifier is 1849616-42-7, is a PEGylated lipid, specifically, ALC0159 is the N, N-dimyristylamide of 2-hydroxyacetic acid, O-pegylated to a PEG chain mass of about 2 kilodaltons. ALC0159 is a non-ionic surfactant by its nature. ALC0159 has been deployed in the Pfizer-BioNTech SARS-CoV-2 mRNA vaccine.
If you have any questions, please don't hesitate to contact us. We're always here to help with Pharmaceutical Excipients for your business. We can provide products ranging from grams to tons. AVT is able to produce and even register the product in US FDA according to your special needs.