AVT (Shanghai) Pharmaceutical Tech Co., Ltd.
ALC-0159

ALC-0159

ALC-0159 cas: 1849616-42-7 is a polyethylene glycol (PEG)-lipid conjugate also called a PEGylated lipid which has been used to form lipid nanoparticles (LNPs) for delivery of RNA. According to public information, ALC0159 is one of the excipients of Pfizer's COVID-19 mRNA vaccine (Comirnaty®). ALC-0159 is a non-ionic surfactant by its nature. It allows forming a hydrophilic layer that enhancing the stabilizes of the nanosystem in polar solvent, contributing to storage stability and reducing non-specific binding to proteins.

This is a reagent grade product, for research use only. Additional information can be found here.


Specifications of ALC-0159


Product nameALC-0159
Chemical name2-[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide
CAS No.1849616-42-7
GradeInjection
Quality standardsmanufacturer's standard
Molecular formulaC31H63NO2(C2H4O)n, n≈45
Content determination≧97%
Molecular weight2464.2
Product CodeO02009
Available Package Sizes1g


What Is Lipid ALC 0159 ?

What is lipid ALC0159? ALC-0159 is an excipient, which refers to a specialized PEG/lipid conjugate  (i.e. PEGylated lipid) that is utilized in the Comirnaty® vaccines. It consists of a PEG moiety that has a mass of 2 kilodaltons and a lipid moiety. LNPs are the current state-of-the-art mRNA delivery systems and typically consist of varying ratios of cholesterol, helper lipid, ionizable lipid and polyethylene glycol (PEG)-lipid. Different from common inert excipients, PEG-lipid plays an important role in LNPs and affects various properties of LNP particles, including LNP particle size and transfection efficiency, etc.


Key Benefits of ALC-0159


Pfizer/Biotechnology COVID-19 vaccine Comirnaty uses ALC0159 to improve the effectiveness of the vaccine.


Advantages and Applications of ALC-0159


ALC-0159, whose chemical identifier is 1849616-42-7, is a PEGylated lipid, specifically, ALC0159 is the N, N-dimyristylamide of 2-hydroxyacetic acid, O-pegylated to a PEG chain mass of about 2 kilodaltons. ALC0159 is a non-ionic surfactant by its nature. ALC0159 has been deployed in the Pfizer-BioNTech SARS-CoV-2 mRNA vaccine.

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If you have any questions, please don't hesitate to contact us. We're always here to help with Pharmaceutical Excipients for your business. We can provide products ranging from grams to tons. AVT is able to produce and even register the product in US FDA according to your special needs.

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