PG

Phosphatidylglycerol (PG) phospholipids carry a negative charge due to their negatively charged polar phosphate groups, rendering the entire molecule negatively charged. Depending on the fatty acid ch...

Phosphatidylglycerol (PG) phospholipids carry a negative charge due to their negatively charged polar phosphate groups, rendering the entire molecule negatively charged. Depending on the fatty acid chains, common PG phospholipids such as dipalmitoylphosphatidylglycerol (DPPG) and dimyristoylphosphatidylglycerol (DMPG) show significant differences in phase transition temperatures.

“DSPG” stands for distearyl phosphatidyl glycerol with two identical stearoyl chains. In the abbreviation, the letter "D" stands for "double," indicating two identical fatty acid...

Liposome particles prepared with DOPG carry a negative charge, allowing them to deliver anticancer drugs across cell membranes and even nuclear membranes into cancer cells. This makes them more effect...

Shrirang, K. have previously demonstrated that using a longer carbon tail length of 22 carbons and unsaturation in the form of 1,2-dierucoyl-sn-glycero-3-phosphoethanolamine (DEPE) as a helper lipid provides dramatic improvement in mRNA delivery, compared to LNPs incorporating the DOPE helper lipid.