As a very stable non-reducing disaccharide, trehalose dihydrate has a magical protective effect on organisms. Trehalose dihydrate forms a unique protective film on the cell surface under harsh environmental conditions such as high temperature, severely cold, high osmotic pressure and watering losing on drying, which can effectively protect protein molecules from invariance, thus maintaining the biological process of organisms.
NMPA CDE registration no.: F20190000452
USFDA DMF no.: 034401
| Product Name | D(+)-Trehalose dihydrate (for injection) |
| Chemical Name | α-D-glucopyranosyl-α-D-glucopyranoside dihydrate |
| CAS No. | 6138-23-4 |
| NMPA CDE registration no. | F20190000452 |
| USFDA DMF No. | 034401 |
| Quality grade | injection |
| Quality standards | Conforms with USP, EP, JP, ChP standards |
| Molecular Formula | C12H22O11·2H2O |
| Applications and examples | Biological products, liposomes, vaccines, CAR-T, stem cells, diagnostic reagents, etc. |
| Product code | O08001 |
| Package sizes | 10kg |
| Storage condition | stored in a cool, dark, and dry place, and transported at room temperature |
It is a commonly used cryoprotectant and an effective lyoprotectant providing maximum protective potency;
Trehalose dihydrate is a non-reducing sugar with higher glass transition temperature and lower hygroscopicity, so it has a wider prospect for application.
Manufactured aseptically in a GMP environment, ultra-low endotoxin (< 0.1 IU/g);
It complies with ChP, USP, JP and EP.
Trehalose dihydrate, one of the most commonly used non-osmotic protectants in cryopreservation, can increase the solute concentration of extracellular solution, which not only can form hypertonicity outside cells, reduces intracellular ice formation, but also has a high glass transition temperature facilitating the transition to a glassy state. On the one hand, the damage of low temperature to cell membrane proteins and lipids is ruled out; on the other hand, the protein molecules of cell membrane are supported and wrapped to prevent deformation, inhibit membrane fusion, and reduce membrane permeability.
If you have any questions, please don't hesitate to contact us. We're always here to help with Pharmaceutical Excipients for your business. We can provide products ranging from grams to tons. AVT is able to produce and even register the product in US FDA according to your special needs.
