AVT (Shanghai) Pharmaceutical Tech Co., Ltd.
phosphatidylethanolamine pegol dspe mpeg2000

Phosphatidylethanolamine Pegol (DSPE-mPEG2000)

DSPE-MPEG2000 is also known as pegylated phosphatidylethanolamine and exists primarily as a salt. It is hygroscopic and soluble in water. Because of the hydrophobicity of DSPE, DSPE-MPEG2000 can form micelles when dissolved in water. The critical micelle concentration (CMC) is less than 10–5 mol/L, more than 100 times smaller than that of surfactants. Therefore, DSPE-MPEG2000 is an excellent drug-loading micelle material.

NMPA CDE registration no.: F20170000595

USFDA DMF no.: 025329


PRODUCT DESCRIPTION

Product namePhosphatidylethanolamine Pegol (DSPE-mPEG2000)
Chemical name
Molecular formulaC133H263NO55PNa
CAS No.147867-65-0
CDE Record registration NumberF20170000595
FDA DMF Number25329
Grade
Quality standards

Sufficient supply, cost-effective
DescriptionWhite powder, odorless, with hygroscopicity
ApplicationsLong-term circulation liposomes, micelles
Molecular weight
Product CodeF01008
Available Package Sizes10kg


Key Benefits of Phosphatidylethanolamine Pegol (DSPE-mPEG2000)

Solubility in water: 1 g is dissolved in 100 ml of distilled water at 25ºC; it is clear and transparent and dissolves fast;

The molecular weight of polyethylene glycol of MPEG2000-DSPE molecule is approximately 2,000, suitable for the preparation of long-circulating liposomes, so that liposomes will not be captured by MPS-rich tissues immediately after intravenous injection, thus prolonging the circulating time in the blood, and further increasing the chances of entering into the pathological tissues.

Better drug-loading stability maintains the particle integrity of micelles even if diluted by blood.


Phosphatidylethanolamine Pegol (DSPE-mPEG2000) Product Properties

White powdery solid with certain hygroscopicity, freely soluble in lower alcohols, ketones and chloroform, solubility in water: approximately (3–4) g/100 ml;

MPEG2000-DSPE can disperse in water to form micelles. The critical micelle concentration (CMC) is 102 times lower than that of surfactants, so the drug-loading stability is better, which maintains the particle integrity of micelles even if diluted by blood.

MPEG2000-DSPE micelles are simpler to prepare than liposomes, and have been proven to be targeted and easier to aggregate in solid tumors.


Have Any Questions?

If you have any questions, please don't hesitate to contact us. We're always here to help with Pharmaceutical Excipients for your business. We can provide products ranging from grams to tons. AVT is able to produce and even register the product in US FDA according to your special needs.

Contact us
sales@avt-cn.com
Address
Room A, 27th Floor, Huadu Mansion, No.838, Zhangyang Road, Pudong District, Shanghai.
Contact AVT
Your Name *
Your Email *
Your Phone
Type Service
Your Message *