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DSPE-MPEG2000 is also known as pegylated phosphatidylethanolamine and exists primarily as a salt. It is hygroscopic and soluble in water. Because of the hydrophobicity of DSPE, DSPE-MPEG2000 can form micelles when dissolved in water. The critical micelle concentration (CMC) is less than 10–5 mol/L, more than 100 times smaller than that of surfactants. Therefore, DSPE-MPEG2000 is an excellent drug-loading micelle material.
| Product name | Phosphatidylethanolamine Pegol (DSPE-mPEG2000) |
| Chemical name | |
| Molecular formula | C133H263NO55PNa |
| CAS No. | 147867-65-0 |
| CDE Record registration Number | F20170000595 |
| FDA DMF Number | 25329 |
| Grade | |
| Quality standards | |
| Sufficient supply, cost-effective | |
| Description | White powder, odorless, with hygroscopicity |
| Applications | Long-term circulation liposomes, micelles |
| Molecular weight | |
| Product Code | F01008 |
| Available Package Sizes | 10kg |
Solubility in water: 1 g is dissolved in 100 ml of distilled water at 25ºC; it is clear and transparent and dissolves fast;
The molecular weight of polyethylene glycol of MPEG2000-DSPE molecule is approximately 2,000, suitable for the preparation of long-circulating liposomes, so that liposomes will not be captured by MPS-rich tissues immediately after intravenous injection, thus prolonging the circulating time in the blood, and further increasing the chances of entering into the pathological tissues.
Better drug-loading stability maintains the particle integrity of micelles even if diluted by blood.
White powdery solid with certain hygroscopicity, freely soluble in lower alcohols, ketones and chloroform, solubility in water: approximately (3–4) g/100 ml;
MPEG2000-DSPE can disperse in water to form micelles. The critical micelle concentration (CMC) is 102 times lower than that of surfactants, so the drug-loading stability is better, which maintains the particle integrity of micelles even if diluted by blood.
MPEG2000-DSPE micelles are simpler to prepare than liposomes, and have been proven to be targeted and easier to aggregate in solid tumors.
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