|Phosphatidylethanolamine Pegol (DSPE-mPEG2000)
|CDE Record registration Number
|FDA DMF Number
|Sufficient supply, cost-effective
|White powder, odorless, with hygroscopicity
|Long-term circulation liposomes, micelles
|Available Package Sizes
Solubility in water: 1 g is dissolved in 100 ml of distilled water at 25ºC; it is clear and transparent and dissolves fast;
The molecular weight of polyethylene glycol of MPEG2000-DSPE molecule is approximately 2,000, suitable for the preparation of long-circulating liposomes, so that liposomes will not be captured by MPS-rich tissues immediately after intravenous injection, thus prolonging the circulating time in the blood, and further increasing the chances of entering into the pathological tissues.
Better drug-loading stability maintains the particle integrity of micelles even if diluted by blood.
White powdery solid with certain hygroscopicity, freely soluble in lower alcohols, ketones and chloroform, solubility in water: approximately (3–4) g/100 ml;
MPEG2000-DSPE can disperse in water to form micelles. The critical micelle concentration (CMC) is 102 times lower than that of surfactants, so the drug-loading stability is better, which maintains the particle integrity of micelles even if diluted by blood.
MPEG2000-DSPE micelles are simpler to prepare than liposomes, and have been proven to be targeted and easier to aggregate in solid tumors.
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