Sucrose Octasulfate Potassium (K-SOS) is a novel excipient. It is used as the raw material for the preparation of Triethylammonium Sucrose Octasulfate salt (TEA-SOS) used in liposome formation.
The excipient K-SOS is transformed into TEA-SOS by ion-exchange. TEA-SOS and the lipids form the liposomes by passive encapsulation following polycarbonate membrane extrusion.
An electrochemical gradient is subsequently formed by removal of TEA-SOS from the exterior of the liposomes by diafiltration.
NMPA CDE registration no.: F20210000349
USFDA DMF no.: 036552
Product Name | Sucrose Octasulfate Potassium |
Chemical Name | / |
CAS No. | 73264-44-5 |
NMPA CDE registration no. | F20210000349 |
USFDA DMF No. | 036552 |
Quality grade | injection |
Quality standards | Comply with ChP, USPpharmacopoeia standards |
Molecular Formula | C12H14K8O35S8 |
Applications and examples | This product, an active substance in the human body, can activate endogenous fibroblast growth factors. It is initially used in drugs for the treatment of ulcers, and later used in liposome preparations as a new excipient. |
Product code | A01001 |
Package sizes | 1kg |
Storage condition | Avoid exposure to strongly acidic, alkaline or oxidizing media. It is valid for two years when used and stored properly. |
Novel excipient for active drug-loading into liposomes.
Pharmaceutical injection grade and compliance with cGMP guideline.
High purity and low endotoxin;
Content of potassium sucrose heptasulfate less than 0.1%.
Novel excipient for active drug-loading into liposomes.
Avoid hydrolysis and inactivation of irinotecan lactone, enhance drug stability, increase half-life, and is more stable than the ammonium sulfate gradient method.
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