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dlin mc3 dma

Dlin-MC3-DMA

DLin-MC3-DMA is one of the most utilized ionizable amino lipids (apparent pKa = 6.44) that is used for making lipid nanoparticles (LNPs) which can encapsulate and deliver siRNA, mRNA, DNA, or small molecules into the cytoplasm. LNP-siRNA systems optimize to achieve maximum gene silencing potency in hepatocytes following IV administration in mice contain DLin-MC3-DMA (MC3), DSPC, cholesterol and a polyethylene glycol (PEG)-lipid at mole ratios of 50/10/38.5/1.5. DLin-MC3-DMA was used in the first FDA approved RNAi treatment consisting of an siRNA targeted to hepatocytes for the treatment of polyneuropathy of hATTR amyloidosis in adults. DLin-MC3-DMA is soluble in ethanol and DMSO. This product is for research only.

SPECIFICATIONS OF DLIN-MC3-DMA CAS NO.:1224606 06 7


Product nameDLin-MC3-DMA
Chemical name(6Z,9Z,28Z,31Z)-heptatriacont-6,9,28,31-tetraene-19-yl 4-(dimethylamino)butanoate
CAS No.1224606-06-7
EINECS registration Number/
CDE Record registration Number/
FDA DMF Number/
GradeInjection
Quality standardsmanufacturer's standard
Molecular formulaC43H79NO2
Content determination≧96%(CAD)
Molecular weight642.1
Product CodeO02006
Available Package Sizes1g


KEY BENEFITS OF DLIN-MC3-DMA CAS NO.:1224606 06 7


DLIN MC3 DMA is pH-sensitive cationic lipid; 

D LIN MC3 DMA has high purity; CDE/DMF registration soon; clinical application-Onpattro: deliver the siRNA.


ADVANTAGES AND APPLICATIONS OF  DLIN-MC3-DMA CAS NO.:1224606 06 7


DLIN DMA is pH-sensitive cationic lipid; DLIN MC3 DMA boasts high purity; MC3 lipid, manufactured under GMP regulations, is going to be registered with CDE/DMF soon; 

DLin-MC3-DMA is an ionizable amino lipid (pKa = 6.44), used in combination with other lipids for encapsulation of RNA and DNA into lipid nanoparticles (LNPs): Onpattro

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