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DOP-DEDA is a charge-reversible phospholipid suitable for preparing lipid nanoparticles (LNPs) for delivering siRNA into cells. Traditional LNPs used for siRNA delivery may aggregate under physiological conditions due to lack of ionization or PEGylation. It has been reported that siRNA-loaded LNPs formulated with DOP-DEDA are always ionized, thus enabling their uptake by cancer cells.
| Product name | DOP-DEDA |
| Chemical name | 2-[(2-Aminoethyl) amino] ethyl (R)-2,3-Bis (oleoyloxy) propyl Hydrogen Phosphate |
| Molecular formula | C43H50N2O8P |
| CAS No. | 2247753-10-0 |
| CDE Record registration Number | |
| FDA DMF Number | |
| Grade | injection |
| Quality standards | |
| Sufficient supply, cost-effective | |
| Description | white powder |
| Applications | |
| Product Code | O02004 |
| Available Package Sizes |
Compared to other ionizable cationic lipids, DOP-DEDA has a wider range of ionizability, does not cause hemolysis under physiological conditions, and exhibits lower toxicity;
Compared to traditional ionizable lipids, the synthesis process of DOP-DEDA is simpler and the cost is lower;
LNPs prepared with DOP-DEDA, DSPC, and CHO do not aggregate even in the absence of PEGylated lipids.
The headgroups of traditional ionizable liposomes contain tertiary amine groups which undergo ionization reactions under different pH conditions, resulting in different charges. The headgroup of DOP-DEDA, however, does not contain a tertiary amine group. Instead, it is composed of phosphate and amino groups. Under various pH conditions, DOP-DEDA undergoes reversible ionization reactions involving its phosphate and amino groups, leading to different charge states of the LNPs formulated with DOP-DEDA.
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