WHAT ARE YOU LOOKING FOR?
Egg phosphatidylglycerol (for injection) EPG, is the PG phospholipid used in alprostadil and is a high-quality auxiliary emulsifier. Phosphatidylglycerol (PG) is a phospholipid present in lung surfactants. Its basic structure is L-glycerol-3-phosphate, with saturated or unsaturated fatty acids linked to ester bonds at positions 1 and 2. Glycerol forms monoester with phosphoric acid. It is the precursor substance of surfactants, and its presence in neonatal amniotic fluid (>0.3) is a symptom of fetal lung maturity.
| Product name | Egg phosphatidylglycerol (for injection) EPG |
| Chemical name | L-α-Phosphatidylglycerol，sodium salt |
| Molecular formula | C40H76NaO10P |
| CAS No. | 383907-64-0 |
| CDE Record registration Number | F20170000042 |
| FDA DMF Number | 008997 |
| Grade | injection Grade |
| Quality standards | Sufficient supply, cost-effective |
| Description | White powder, odourless. |
| Applications | Alprostadil injection, liposomes |
| Product Code | N01004 |
| Available Package Sizes | 1kg |
1. Stabilization and co-emulsification;
2. Improve the validity period of alprostadil liposome, verteporfin liposome and alprostadil injection.
1. The unique structure, physical and chemical properties have played an critical role in the development of some key preparations. Among them, the most outstanding representative is the alprostadil injection launched by Fuji Pharmaceutical in January 2014 with shelf life of two-year .
2. In addition, EPG has also been applied in the development of some liposome drugs. Due to its characteristics of lower phase transition temperature, low rigidity, negative charge, etc., EPG's application is different from saturated PG phospholipids such as DPPG. EPG is usually used to develop poorly soluble drugs or liposomes with special requirements.
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