Egg phosphatidylglycerol (for injection) EPG, is the PG phospholipid used in alprostadil and is a high-quality auxiliary emulsifier. Phosphatidylglycerol (PG) is a phospholipid present in lung surfactants. Its basic structure is L-glycerol-3-phosphate, with saturated or unsaturated fatty acids linked to ester bonds at positions 1 and 2. Glycerol forms monoester with phosphoric acid. It is the precursor substance of surfactants, and its presence in neonatal amniotic fluid (>0.3) is a symptom of fetal lung maturity.
NMPA CDE registration no.: F20170000042
USFDA DMF no.: 008997
Product Name | Egg phosphatidylglycerol (for injection) EPG |
Chemical Name | L-α-Phosphatidylglycerol，sodium salt |
CAS No. | 383907-64-0 |
NMPA CDE registration no. | F20170000042 |
USFDA DMF No. | 008997 |
Quality grade | Injection |
Quality standards | Conforms with USP, JP, ChP standards |
Molecular Formula | C42H80NaO9P |
Applications and examples | EPG has characteristics such as a low phase transition temperature, good flexibility, and negative charge,making it commonly used in the development of liposomal drugs for poorly soluble drugs or those with special requirements. Additionally, EPG can be used as an emulsifier to prepare lipid emulsions, with a notable example being Fuji Pharma’s second-generation alprostadil injection, which has a shelf life of two years. |
Product code | N01004 |
Package sizes | 1kg |
Storage condition | This product should be transported and stored in a sealed and light-protected container under freezing conditions. It should be kept away from strong oxidizing agents. Under proper use and storage conditions, it is valid for three years, with retesting conducted annually. |
1. Stabilization and co-emulsification;
2. Improve the validity period of alprostadil liposome, verteporfin liposome and alprostadil injection.
1. The unique structure, physical and chemical properties have played an critical role in the development of some key preparations. Among them, the most outstanding representative is the alprostadil injection launched by Fuji Pharmaceutical in January 2014 with shelf life of two-year .
2. In addition, EPG has also been applied in the development of some liposome drugs. Due to its characteristics of lower phase transition temperature, low rigidity, negative charge, etc., EPG's application is different from saturated PG phospholipids such as DPPG. EPG is usually used to develop poorly soluble drugs or liposomes with special requirements.
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