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Dioleoylphosphatidylethanolamine (DOPE) is one of the most widely used auxiliary phospholipids, exhibiting strong synergistic effects in the preparation of cationic liposomes. Applications: liposomes, lipid nanoparticles, and modulation of phospholipid membrane fluidity.
| Product name | 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine DOPE |
| Chemical name | Neutral helper phospholipid that facilitates lysosomal escape |
| Molecular formula | C41H78NO8P |
| CAS No. | 4004/5/1 |
| CDE Record registration Number | |
| FDA DMF Number | 028884 |
| Grade | |
| Quality standards | |
| Sufficient supply, cost-effective | |
| Description | It is one of the most widely used lipid promoters and has a strong synergistic effect in the preparation of cationic liposomes. |
| Applications | Liposomes, lipid nanoparticles, regulate phospholipid membrane fluidity |
| Product Code | S03005 |
| Available Package Sizes |
Adding DOPE in cationic liposomes can enhance the membrane fusion capability, leading to higher stability and lower cytotoxicity. Lipopolymer alone cannot achieve cell transfection, but the combination of lipopolymer with DOPE can accomplish this. For example, DOPE plays a role in CAT gene transfection, whereas the DC-Chol/DOPC lipid complex does not exhibit this activity.
DOPE is a neutral, unstable auxiliary phospholipid, which stabilizes the bilayer membrane and reduces the toxicity of cationic components;
It can disrupt lipid membranes, destabilizing the endosomal membrane within cells to promote the release of DNA and RNA, and assisting cationic liposomes in penetrating cells;
It can also determine the morphology of nucleic acid-liposome complexes, transitioning lipid structures from the lamellar Lα phase to the hexagonal HII phase, thereby enhancing the fusogenicity of the complexes and significantly improving transmembrane efficiency.
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