As a commonly used helper lipid, DOPE exhibits strong synergistic effects in the preparation of cationic liposomes. Liposomes formulated with DOPE have been developed into commercial transfection reagents and are widely used in basic research. Additionally, DOPE is also an essential helper lipid in cationic lipid formulations and marketed liposomal vaccines such as Epaxal and Inflexal V.
| Product name | 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine DOPE |
| Chemical name | Neutral helper phospholipid that facilitates lysosomal escape |
| Molecular formula | C41H78NO8P |
| CAS No. | 4004/5/1 |
| CDE Record registration Number | |
| FDA DMF Number | 028884 |
| Grade | |
| Quality standards | |
| Sufficient supply, cost-effective | |
| Description | It is one of the most widely used lipid promoters and has a strong synergistic effect in the preparation of cationic liposomes. |
| Applications | Liposomes, lipid nanoparticles, regulate phospholipid membrane fluidity |
| Product Code | S03005 |
| Available Package Sizes |
DOPE is the most commonly used helper lipid. Liposomes prepared using DOPE demonstrate better fusogenicity and transfection efficiency compared to those prepared using DOPC or CHO. DOPE can facilitate self-assembly and endosomal escape of liposomes. When combined with cationic lipids, DOPE can enhance the transfection efficiency of naked siRNA.
DOPE is a phosphatidylethanolamine with two unsaturated chains (C18). The unsaturated tails facilitate the formation of more fluid lipid bilayers and can also adopt a hexagonal (HII) phase. The HII phase aids in promoting fusion between lipid bilayers and intracellular membranes, facilitating the release of nucleic acids into the cytoplasm.
DOPE is a neutral, unstable auxiliary phospholipid, which stabilizes the bilayer membrane and reduces the toxicity of cationic components;
It can disrupt lipid membranes, destabilizing the endosomal membrane within cells to promote the release of DNA and RNA, and assisting cationic liposomes in penetrating cells;
It can also determine the morphology of nucleic acid-liposome complexes, transitioning lipid structures from the lamellar Lα phase to the hexagonal HII phase, thereby enhancing the fusogenicity of the complexes and significantly improving transmembrane efficiency.
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