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1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine DOPE

Dioleoylphosphatidylethanolamine (DOPE) is one of the most widely used auxiliary phospholipids, exhibiting strong synergistic effects in the preparation of cationic liposomes. Applications: liposomes, lipid nanoparticles, and modulation of phospholipid membrane fluidity.

Specifications of 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine DOPE

Product name1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine DOPE
Chemical nameNeutral helper phospholipid that facilitates lysosomal escape
Molecular formulaC41H78NO8P
CAS No.4004/5/1
CDE Record registration Number
FDA DMF Number028884
Quality standards

Sufficient supply, cost-effective
DescriptionIt is one of the most widely used lipid promoters and has a strong synergistic effect in the preparation of cationic liposomes.
ApplicationsLiposomes, lipid nanoparticles, regulate phospholipid membrane fluidity
Product CodeS03005
Available Package Sizes

Key Benefits of 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine DOPE

Adding DOPE in cationic liposomes can enhance the membrane fusion capability, leading to higher stability and lower cytotoxicity. Lipopolymer alone cannot achieve cell transfection, but the combination of lipopolymer with DOPE can accomplish this. For example, DOPE plays a role in CAT gene transfection, whereas the DC-Chol/DOPC lipid complex does not exhibit this activity.

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine DOPE Product Properties

DOPE is a neutral, unstable auxiliary phospholipid, which stabilizes the bilayer membrane and reduces the toxicity of cationic components;

It can disrupt lipid membranes, destabilizing the endosomal membrane within cells to promote the release of DNA and RNA, and assisting cationic liposomes in penetrating cells;

It can also determine the morphology of nucleic acid-liposome complexes, transitioning lipid structures from the lamellar Lα phase to the hexagonal HII phase, thereby enhancing the fusogenicity of the complexes and significantly improving transmembrane efficiency.

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