AVT (Shanghai) Pharmaceutical Tech Co., Ltd.
c12 200

C12-200

C12-200 is an ionizable cationic lipid and helper lipid. Its cationic properties enable it to effectively bind with negatively charged nucleic acids (such as mRNA), thus facilitating intracellular nucleic acid delivery. Research has proposed a method for preparing freeze-dried C12-200vmRNA LNPs utilizing a continuous freeze-drying technique based on spin-freezing. 


PRODUCT DESCRIPTION

Product NameC12-200
Chemical Name1-[2-[Bis(2-hydroxydodecyl) amino] ethyl-[2-[4-[2-[bis(2-hydroxydodecyl) amino] ethyl] piperazin-1-yl] ethyl] amino] dodecan-2-ol
CAS No.

1220890-25-4

NMPA CDE registration no./
USFDA DMF No./
Quality gradeInjection
Quality standardsManufacturer's standard
Molecular FormulaC70H145N5O5
Applications and examplesIt can be used in combination with other lipids to form lipid nanoparticles (LNPs) by self-assembly for delivery of messenger RNA (mRNA), small interfering RNA (siRNA) or self-amplifying RNA (saRNA).
Product codeE01002
Package sizes10g;50g
Storage conditionPure form,-20°C,3 years
4°C,2 years


Advantages of C12-200

C12-200 can effectively deliver siRNA in vivo and achieve efficient gene silencing effects at low doses.


C12-200 Product Properties

C12-200 is a multi-tail and branched-chain ionizable lipid with five hydroxyl groups. Its structure allows it to form more cone-like structures within cells, thereby enhancing its intracellular efficacy, particularly its ability to disrupt endosomes.

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