Product Name | DOTAP |
Chemical Name | 1,2-Dioleoyl-3-trimethylammonium-propane, Chloride |
CAS No. | 132172-61-3 |
NMPA CDE registration no. | / |
USFDA DMF No. | / |
Quality grade | Injection |
Quality standards | manufacturer's standard |
Molecular Formula | C42H80ClNO4 |
Applications and examples | cationic polymer, cationic liposome |
Product code | O02002 |
Package sizes | 1g;10g;50g |
Storage condition |
High transfection efficiency: As a gene transfection reagent in commercial products, DOTAP offers a significantly gentler transfection process. Compared to other lipid-based transfection agents, it helps to mitigate cytotoxic effects and ensures a higher transfection efficiency.
Targeted Delivery: DOTAP can serve as a supplementary component in selective organ targeting (SORT) lipid nanoparticles (LNPs). Incorporating 10%-15% DOTAP in LNPs facilitates targeted drug delivery to the spleen, while increasing the DOTAP content to 50% achieves optimal lung delivery efficiency.
DOTAP is biologically inert, biodegradable, non-toxic, and non-immunogenic. Its polar head stably binds to negatively charged DNA molecules through electrostatic interactions, forming stable complexes spontaneously that enter cells and deliver nucleic acids into the cytoplasm without causing damage to the organism. It is therefore often used as a vector for eukaryotic transfection reagents and DNA vaccines.
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