DSPA is a form of phosphatidic acid (PA), and it is an essential component of the cell membrane, playing a significant role in biophysics, metabolic processes, and signal transmission. PA exhibits a variety of functions in the biochemistry and physiology of animal cells, including cell proliferation and differentiation, cellular transformation, tumor progression, and signal transduction for the maintenance of life functions.
| Chemical name | 1,2-Distearoyl-sn-glycero-3-phosphate (sodium salt) |
| Molecular formula | C39H76O8PNa |
| CAS number | 108321-18-2 |
| Manufacturer | AVT (Shanghai) Pharmaceutical Tech Co., Ltd. / A.V.T. |
| Grade | reagent grade |
| NMPA registration number | N/A |
| DMF number | N/A |
| EINECS number | N/A |
| Specifications | in-house |
| Description | white powder |
| Purity | N/A |
| Solubility | N/A |
| Molecular weight | 726.99 |
| pKa | N/A |
| Phase transition temperature | unknown |
As a part of the double membrane, DSPA is used to study its role in the formation of vesicle lysis, particularly with the influence on factors associated with coat protein I (COPI).
DSPA is also utilized to investigate its impact on the changes in calcium ion (Ca2+) concentration within C6 rat glioma and L2071 mouse fibroblasts.
DSPA is additionally used to explore its effects on the phosphorylation of cytochrome b (558)-alpha chain (also known as p22phox).
DSPA acts as a biosynthetic precursor for producing membrane glycerophospholipids and triacylglycerols, participates in the regulation of the mammalian target of rapamycin (mTOR) pathway, and is involved in membrane transportation, primarily via membrane fusion and fission.
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