AVT (Shanghai) Pharmaceutical Tech Co., Ltd.
dopc

1,2-Dioleoyl-sn-glycero-3-phosphocholine(for injection) DOPC


The injection-grade DOPC supplied by A.V.T. features high stability and purity, making it suitable for use as a membrane material in liposomes. Due to its lower phase transition temperature and susceptibility to oxidation owing to its double bond structure, its application is not as widespread as that of DSPC, HSPC, and others. However, it serves as a crucial excipient in many commercially available liposomal products, such as liposomal cytarabine, liposomal morphine sulfate, Epaxal, Inflexal V, and Shingrix.

NMPA CDE registration no.: F20190000371

USFDA DMF no.: 028883


PRODUCT DESCRIPTION

Product nameDOPC
Chemical name1,2-Dioleoyl-sn-Glycero-3-Phosphocholine
CAS No.4235-95-4
EINECS registration Number224-193-8
CDE Record registration NumberF20190000371
FDA DMF Number028883
GradeInjection
Quality standardsmanufacturer's standard
Molecular formulaC44H84NO8P
Content determination≧99%
Molecular weight786.1
Product CodeS01007
Available Package Sizes1g; 10g; 50g


Advantages: 

Its lower phase transition temperature makes it suitable for liposome preparation;

Its unsaturated fatty acid tail structure renders the liposome membrane more prone to disruption, aiding in the release of payloads and thereby enhancing mRNA delivery effectiveness.


Properties: 

DOPC (18:1 PC) tends to be viscous, prone to lump formation, and susceptible to moisture absorption. Therefore, special attention should be paid for storage, preferably at -20°C, with proper sealing and protection from light to prevent any adverse effects on its quality and shelf life. Additionally, as phospholipids are prone to hydrolysis in strong acidic or alkaline environments, it is important to avoid DOPC contact with strong acid or alkali media.


Have Any Questions?

If you have any questions, please don't hesitate to contact us. We're always here to help with Pharmaceutical Excipients for your business. We can provide products ranging from grams to tons. AVT is able to produce and even register the product in US FDA according to your special needs.

Contact us
sales@avt-cn.com
Address
Room A, 27th Floor, Huadu Mansion, No.838, Zhangyang Road, Pudong District, Shanghai.
Contact AVT
Your Name *
Your Email *
Your Phone
Type Service
Your Message *