Mar 23, 2023
Egg yolk lecithin is a mixture of phospholipids, mainly phosphatidylcholine (PC), and its physiological effects are mainly related to the function of PC. It is a milky-white or pale yellow powder or w...
Mar 07, 2023
Many liquid phase methods usebuffer salts. It has been found that many people do not understand the application of buffer salts in liquid phase methods, so I would like to share some of my views and s...
Mar 01, 2023
In reversed-phase chromatography, the pH of the mobile phase is generally between 2-7. When the analyte can dissociate under reversed-phase conditions, or when the pH of the sample is outside the rang...
Feb 15, 2023
mRNA vaccines are in urgent need of extended shelf life and improved storage conditionsAccording to data released by the World Health Organization (WHO) on October 10, 2022, the cumulative number of c...
Feb 08, 2023
Recently, Moderna held the Fifth Science and Technology Day. In the report, the company presented recent advances in modified mRNA therapy delivery and stability.The mRNA itself is unstable, so improv...
Feb 01, 2023
Pfizer/BioNTech uses RNase-free HEPES buffer during the manufacturing of mRNA COVID-19 vaccinesThe EMA review report for Pfizer/BioNTech’s COVID-19 vaccines mentioned that the manufacturing of active...
Dec 21, 2022
This document provides information of cholesterol, a non-mysterious reagent that has been used in liposomes, LNPs and even adjuvants (AS01B). Its nature, structure and role are familiar to us. Let’s ...
Dec 14, 2022
On December 9, 2020, DOPC versus DOPE as a helper lipid for gene-therapies: molecular dynamics simulations with DLin-MC3-DMA was published on PCCP (Phys Chem Chem Phys) [1]. In this paper, two liposom...