AVT (Shanghai) Pharmaceutical Tech Co., Ltd.
alc 0315


ALC-0315 is an ionizable amino lipid that can significantly enhance the efficiency of LNP-mediated mRNA delivery and ensure effective mRNA escape from endosomes within cells, thereby enhancing gene transfection. As an ionizable cationic lipid approved for clinical RNA therapeutics, it has been utilized in the development of mRNA vaccines for COVID-19. It serves as the cationic lipid component in the BNT162b vaccine against COVID-19. 


Product nameALC-0315
Chemical name[(4-Hydroxybutyl)azanediyl]di(hexane-6,1-diyl) bis(2-hexyldecanoate)
CAS No.2036272-55-4
EINECS registration Number/
CDE Record registration Number/
FDA DMF Number/
Quality standardsmanufacturer's standard
Molecular formulaC48H95NO5
Content determination≧98%
Molecular weight766.3
Product CodeO02008
Available Package Sizes1g


ALC-0315 possesses several advantages such as self-assembly, easy preparation, and high stability. It effectively shields negatively charged drugs or nucleic acids from enzymatic degradation, enhances their cellular uptake, and improves their bioavailability.


ALC-0315 features a terminal hydroxyl group in its head group, which can effectively reduce hydration while enhancing hydrogen bonding interactions with nucleic acids, potentially boosting its transfection efficiency. Additionally, it has good biodegradability due to the introduction of ester bonds in the tail, thereby shortening the half-life of ALC-0315-containing drugs in vivo.

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