ALC-0315 is an ionizable amino lipid that can significantly enhance the efficiency of LNP-mediated mRNA delivery and ensure effective mRNA escape from endosomes within cells, thereby enhancing gene transfection. As an ionizable cationic lipid approved for clinical RNA therapeutics, it has been utilized in the development of mRNA vaccines for COVID-19. It serves as the cationic lipid component in the BNT162b vaccine against COVID-19.
| Product Name | ALC-0315 |
| Chemical Name | ((4-Hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate) |
| CAS No. | 2036272-55-4 |
| NMPA CDE registration no. | / |
| USFDA DMF No. | / |
| Quality grade | Reagent |
| Quality standards | manufacturer's standard |
| Molecular Formula | C48H95NO5 |
| Applications and examples | This product is an ionizable amino lipid with pH variability. ALC-0315 has good biodegradability and short in vivo half-life because of the introduced ester bond at the lipid tail. It is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release, and can be used for preparation of lipid delivery systems for various nucleic acid drugs and nucleic acid vaccines. It can also be used as one of the components of lipid nanoparticle (LNP) delivery systems for mRNA-based vaccines. |
| Product code | O02008 |
| Package sizes | 1g |
| Storage condition | The product should be transported in a refrigerator, protected from light (for less than 2 weeks). It should be stored at -20 ± 5℃ in an inert atmosphere, protected from light. To avoid water absorption, naturally warm up to room temperature before unpacking. It is valid for 1 year when used and stored properly. |
ALC-0315 possesses several advantages such as self-assembly, easy preparation, and high stability. It effectively shields negatively charged drugs or nucleic acids from enzymatic degradation, enhances their cellular uptake, and improves their bioavailability.
ALC-0315 features a terminal hydroxyl group in its head group, which can effectively reduce hydration while enhancing hydrogen bonding interactions with nucleic acids, potentially boosting its transfection efficiency. Additionally, it has good biodegradability due to the introduction of ester bonds in the tail, thereby shortening the half-life of ALC-0315-containing drugs in vivo.
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