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SM102（Formal Name：8-[(2-hydroxyethyl)[6-oxo-6-(undecyloxy)hexyl]amino]-octanoic acid, 1-octylnonyl ester，CAS Number：2089251-47-6）is an ionizable amino lipid that can be used for the formation of lipid nanoparticles (LNPs). It is one of the essential ingredients present in the Moderna COVID-19 vaccine. SM-102 hold a neutral charge at physiological pH but are positively charged at acidic pH (the amine group is protonated to form an ammonium cation). This allows them to bind to the negatively charged backbone of mRNA. The rest of the lipid nanoparticle is formed from PEGylated lipids, which help stabilize the particle, and phospholipids and cholesterol molecules that contribute to the particle’s structure. The lipid nanoparticles enter the cells by triggering receptor-mediated endocytosis, then the delivered mRNA was released into the cytoplasm through endosomal escape.
For research purposes only, SM-102 is commonly used as an efficient pharmaceutical compound. As a leading SM 102 manufacturer, we ensure the quality of our product is the highest standard.
| Product name | SM-102 |
| Chemical name | 9-Heptadecanyl 8-{(2-hydroxyethyl)[6-oxo-6-(undecyloxy)hexyl]amino}octanoate |
| CAS No. | 2089251-47-6 |
| EINECS registration Number | / |
| CDE Record registration Number | / |
| FDA DMF Number | / |
| Grade | Injection |
| Quality standards | manufacturer's standard |
| Molecular formula | C44H87NO5 |
| Content determination | ≧95% |
| Molecular weight | 710.2 |
| Product Code | O02010 |
| Available Package Sizes | 1g; 5g |
A pH-sensitive cationic lipid; Moderna Covide-19 vaccine: SpikeVax
Lipide sm102 is a pH-sensitive cationic lipid; SM-102 is a synthetic amino lipid which is used in combination with other lipids to form lnp nanoparticles. These are used for the delivery of mRNA-based vaccines, and in particular SM-102 forms part of the drug delivery system for the Moderna COVID-19 vaccine SpikeVax. As such, SM 102 sm102 lipid moderna plays an important role in the development and distribution of vaccines. Contact SM 102 manufacturer AVT if you want to know more.
If you have any questions, please don't hesitate to contact us. We're always here to help with Pharmaceutical Excipients for your business. We can provide products ranging from grams to tons. AVT is able to produce and even register the product in US FDA according to your special needs.
