The ionizable cationic amino lipid SM-102 is commonly used to encapsulate and deliver nucleic acid (e.g., mRNA or siRNA) drugs as well as other bioactive substances and plays an important role in the development of mRNA therapeutics and vaccines with lipid nanoparticles (LNPs) as delivery carriers. It has also been used in the mRNA-LNP COVID-19 vaccine mRNA-1273 (Moderna).
| Product Name | SM-102 |
| Chemical Name | 1-octylnonyl8- [(2-hydroxyethyl) [6-oxo-6- (undecyloxy) hexyl] amino] -octanoate |
| CAS No. | 2089251-47-6 |
| NMPA CDE registration no. | / |
| USFDA DMF No. | / |
| Quality grade | Reagent |
| Quality standards | manufacturer's standard |
| Molecular Formula | C44H87NO5 |
| Applications and examples | SM-102 is an amino cationic lipid designed for the assembly of nucleic acid delivery lipid nanoparticles. It is also one of the basic components of the COVID-19 vaccine mRNA-1273 developed by Moderna. Cations carried by SM-102 can bind with negatively charged mRNA through electrostatic interaction, and self-assemble with phospholipids to form lipid nanoparticles, to escort mRNA into the cells through endocytosis and release in time; and the free mRNA is translated in the ribosome to form antigens, thereby achieving an immune response. |
| Product code | O02010 |
| Package sizes | 1g;5g |
| Storage condition | The product should be transported in a refrigerator, protected from light (for less than 2 weeks). It should be stored at -20 ± 5℃ in an inert atmosphere, protected from light. To avoid water absorption, naturally warm up to room temperature before unpacking. It is valid for 1 year when used and stored properly. |
1. SM-102 carries a positive charge and exhibits excellent biocompatibility, which enables it to form complexes with negatively charged nucleic acids, to protect nucleic acids from degradation and facilitate their entry into cells and subsequent release into the cytoplasm.
2. Using LNPs formulated with SM-102 to deliver luciferase mRNA can induce luciferase expression in the mouse liver, demonstrating the significance of SM-102 in drug delivery and gene transfection.
The cationic lipid SM-102 is a light-yellow oil composed of phospholipids and cationic surfactants. It carries a positive charge at low pH but remains neutral at physiological pH. Due to its neutralization under physiological conditions, it can reduce interactions with anionic cell membranes, enhancing intracellular delivery of LNPs formulated with SM-102 and thereby improving gene transfection efficiency.
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