What is excipients in pharma? In the production process of oral solid preparations, there are certain principles for the selection of pharmaceutical excipients to ensure the safety and stability of the drug. This is a basic principle for selecting pharmaceutical excipients. Currently, there is more and more research on pharmaceutical excipients for oral solid preparations, and the following experiences have been gained in the selection process.
A basic principle for selecting pharmaceutical excipients is that they should have no adverse effects on the drug, meaning they should not reduce the drug's efficacy, cause any toxic side effects, or interfere with the quality of the preparations. Therefore, during the selection process, excipients with stable physical, chemical, and biological properties should be chosen.
Before selecting excipients, it is necessary to understand various parameters such as the basic performance, quality specifications, and compatibility prohibitions of the excipients. It is crucial to understand the compatibility, fluidity, viscosity, and other indicators between the excipients and oral solid preparations. This knowledge can help strengthen the reasonable selection and application of excipients in the production process of oral solid preparations, preventing any negative impacts due to improper selection.
In the excipient selection process, it is necessary to choose according to the production process of oral solid preparations. Therefore, understanding the production process of oral solid preparations is crucial to selecting the appropriate pharma excipients based on specific production processes. Common processes in the production of oral solid preparations include wet granulation, direct compression, and fluidized bed granulation. The dosage forms of the drugs formed in different production processes are different. Thus, excipients should be selected according to the specific drug manufacturing process to improve the quality of the drugs.
During the selection of excipients, it is necessary to select according to the dosage of the drug, following the principle of minimal required quantity that ensures the shaping, effectiveness, and stability of oral solid preparations. The amount of excipients should be effectively controlled to avoid wastage of raw materials. However, to save costs, the dosage should not be insufficient. Cost reduction can be achieved under the premise of ensuring drug efficacy.
The production process of pharmaceuticals cannot do without excipients. The application of pharma excipients can effectively improve the safety and stability of the drug production process. Currently, there is increasing research and application of pharma excipients. Strengthening the selection and application of pharmaceutical excipients in the drug production process can effectively enhance the production level of oral solid preparations.
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