AVT (Shanghai) Pharmaceutical Tech Co., Ltd.

TRIS Product Introduction (provided by the customer)

1. Product introduction


Tromethamine (Tris) is a buffer salt widely used in the field of biomedicine. Its chemical formula is C4H11NO3, and it is a white crystalline particle. It is commonly used in protein or nucleic acid buffers, and the effective range is usually between pH 7.0-9.2. Tris has also been used for protein crystal growth at different pH conditions. Tris is also one of the main components of protein electrophoresis buffer. It forms a buffer system with glycine in the electrophoresis buffer to stabilize the pH during electrophoresis. In addition, Tris is also an intermediate in the preparation of surfactants, vulcanization accelerators and some drugs, and is also used as a titration standard.


2. Application cases


The specific application cases of Tris are as follows.


① ModernaCOVID-19 nucleic acid and vaccine buffer (mRNA-1273, pH7.0-8.0)


Uses: Buffer for mRNA-LNP complexes.

Element

mRNA

SM-102

DMG-PEG2000

DSPC

cholesterol

Tris

The molar ratio of

-

50

10

38.5

1.5

-


② pH buffer (0.5M, pH7.6)

Application: Buffer for protein or nucleic acid.

Element

Tris

HCl (1N)

H 2 O

content

60.57g

420ml

Add to 1000ml


③ Ammonium Tromethrate Injection

purposes : acid-base balance regulator. For acute respiratory, metabolic acidemia.

Element

Tris

(7.28%)

Glucose solution (5-10%)

content

equal mix

Other applications such as carboprost tromethamine injection, contrast agents (iohexol, iopromide, etc.).


3. Product advantages


AVT launched a new tromethamine product (CDE, DMF registration). Our products have the advantages of high purity and low impurities, production under GMP conditions, stable supply of localization, and high cost performance. Welcome to private message for trial!