Tromethamine (Tris) is buffer salts widely used in the field of biomedicine. Its chemical formula is C4H11NO3, and it is a white crystalline particle. It is commonly used in protein or nucleic acid buffers, and the effective range is usually between pH 7.0-9.2. Tris has also been used for protein crystal growth at different pH conditions. Tris is also one of the main components of protein electrophoresis buffer. It forms a buffer system with glycine in the electrophoresis buffer to stabilize the pH during electrophoresis. In addition, tromethamine tris is also an intermediate in the preparation of surfactants, vulcanization accelerators and some drugs, and is also used as a titration standard.
The specific application cases of Tris are as follows.
① ModernaCOVID-19 nucleic acid and vaccine buffer (mRNA-1273, pH7.0-8.0)
Uses: Buffer for mRNA-LNP complexes.
The molar ratio of
② pH buffer (0.5M, pH7.6)
Application: Buffer for protein or nucleic acid.
H 2 O
Add to 1000ml
③ Ammonium Tromethrate Injection
purposes : acid-base balance regulator. For acute respiratory, metabolic acidemia.
Glucose solution (5-10%)
Other applications such as carboprost tromethamine injection, contrast agents (iohexol, iopromide, etc.).
AVT ltd launched a new tromethamine product (CDE, DMF registration). Our products have the advantages of high purity and low impurities, production under GMP conditions, stable supply of localization, and high cost performance. Welcome to private message for trial!