DOPS is an excellent substitute for phosphatidylserine (PS) naturally occurring in the brain, with similar physical properties. It has been used in combination with DOPC and DOPE in lipid mixtures to simulate the platelet membrane used in coagulation studies.
| Chemical name | 1,2-dioleoyl-sn-glycero-3-phospho-L-serine (sodium salt) |
| Molecular formula | C42H77NO10PNa |
| CAS number | 90693-88-2 |
| Manufacturer | AVT (Shanghai) Pharmaceutical Tech Co., Ltd. / A.V.T. |
| Grade | reagent grade |
| NMPA registration number | N/A |
| DMF number | N/A |
| EINECS number | N/A |
| Specifications | in-house |
| Description | white powder |
| Purity | N/A |
| Solubility | N/A |
| Molecular weight | 810.03 |
| pKa | N/A |
| Phase transition temperature | unknown |
Preparation of liposomes (multilamellar vesicles), and as a component of the incubation buffer for measuring exosome-related procoagulant activity.
In laboratory studies, DOPS is used to construct liposome models to study the interaction between liposomes and proteins, as well as cell membrane functions. Due to its negative charge, it is also commonly used to simulate the negatively charged environment inside the cell.
DOPS is a derivative of PS, consisting of two oleoyl chains attached to the headgroup of negatively charged phosphoglycerolamine.
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