Product name | Dlin-MC3-DMA |
Chemical name | 4-(dimethylamino)-butanoic acid, (10Z, 13Z)-1-(9Z, 12Z) -9, 12-octadecadien-1-yl-10, 13-nonadecadien-1-yl ester |
Molecular formula | C43H79NO2 |
CAS No. | 1224606-06-7 |
CDE Record registration Number | |
FDA DMF Number | |
Grade | reagent |
Quality standards | |
Sufficient supply, cost-effective | |
Description | Colorless to pale yellow oily liquid, odorless |
Applications | Onpattro (2018)-siRNA Delivery Vector |
Product Code | O02006 |
Available Package Sizes |
Low toxicity: DLin-MC3-DMA is a pH-responsive ionizable lipid, whereby it adopts a positive charge at low pH and has near-neutral charge at physiological pH. This means that, when forming lipid nanoparticles (LNPs) encapsulating nucleic acids under acidic conditions, it exhibits minimal positive charge density in the bloodstream, resulting in low cellular toxicity.
High efficiency: LNPs formed with DLin-MC3-DMA exhibit positive charge, facilitating lysosomal SiRNA escape to enhance transfection efficiency and reducing phagocytosis by macrophages.
DLin-MC3-DMA is a colorless to yellowish oily liquid with a pKa of 6.44. The functional activity of LNPs is correlated with the pKa value of the cationic lipid used. LNPs formed with DLin-MC3-DMA with a pKa of 6.2 to 6.5 exhibit higher gene-silencing activity.
If you have any questions, please don't hesitate to contact us. We're always here to help with Pharmaceutical Excipients for your business. We can provide products ranging from grams to tons. AVT is able to produce and even register the product in US FDA according to your special needs.