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The injection-grade DOPC supplied by A.V.T. features high stability and purity, making it suitable for use as a membrane material in liposomes. Due to its lower phase transition temperature and susceptibility to oxidation owing to its double bond structure, its application is not as widespread as that of DSPC, HSPC, and others. However, it serves as a crucial excipient in many commercially available liposomal products, such as liposomal cytarabine, liposomal morphine sulfate, Epaxal, Inflexal V, and Shingrix.
| Product name | 1.1,2-Dioleoyl-sn-glycero-3-phosphocholine(for injection) DOPC |
| Chemical name | |
| Molecular formula | C44H84NO8P |
| CAS No. | 4235-95-4 |
| CDE Record registration Number | F20190000371 |
| FDA DMF Number | |
| Grade | injection |
| Quality standards | Conforms with USP, JP, ChP standards |
| Sufficient supply, cost-effective | |
| Description | white to yellowish, odorless viscous solid |
| Applications | Cytarabine, Morphine Sulfate Liposome, liposome vaccine |
| Product Code | S01007 |
| Available Package Sizes |
Its lower phase transition temperature makes it suitable for liposome preparation;
Its unsaturated fatty acid tail structure renders the liposome membrane more prone to disruption, aiding in the release of payloads and thereby enhancing mRNA delivery effectiveness.
DOPC (18:1 PC) tends to be viscous, prone to lump formation, and susceptible to moisture absorption. Therefore, special attention should be paid for storage, preferably at -20°C, with proper sealing and protection from light to prevent any adverse effects on its quality and shelf life. Additionally, as phospholipids are prone to hydrolysis in strong acidic or alkaline environments, it is important to avoid DOPC contact with strong acid or alkali media.
If you have any questions, please don't hesitate to contact us. We're always here to help with Pharmaceutical Excipients for your business. We can provide products ranging from grams to tons. AVT is able to produce and even register the product in US FDA according to your special needs.
