AVT (Shanghai) Pharmaceutical Tech Co., Ltd.
sm 102


The ionizable cationic amino lipid SM-102 is commonly used to encapsulate and deliver nucleic acid (e.g., mRNA or siRNA) drugs as well as other bioactive substances and plays an important role in the development of mRNA therapeutics and vaccines with lipid nanoparticles (LNPs) as delivery carriers. It has also been used in the mRNA-LNP COVID-19 vaccine mRNA-1273 (Moderna).

Product Description

Product nameSM-102
Chemical name1-octylnonyl8- [(2-hydroxyethyl) [6-oxo-6- (undecyloxy) hexyl] amino] -octanoate
Molecular formulaC44H87NO5
CAS No.2089251-47-6
CDE Record registration Number
FDA DMF Number
Quality standards

Sufficient supply, cost-effective
DescriptionPale yellow oily liquid
ApplicationsmRNA-1273 (2020)-mRNA COVID-19 Vaccine
Product CodeO02010
Available Package Sizes

Key Benefits of youdain SM-102

SM-102 carries a positive charge and exhibits excellent biocompatibility, which enables it to form complexes with negatively charged nucleic acids, to protect nucleic acids from degradation and facilitate their entry into cells and subsequent release into the cytoplasm.

Using LNPs formulated with SM-102 to deliver luciferase mRNA can induce luciferase expression in the mouse liver, demonstrating the significance of SM-102 in drug delivery and gene transfection.

SM-102 Product Properties

DLin-MC3-DMA is a colorless to yellowish oily liquid with a pKa of 6.44. The functional activity of LNPs is correlated with the pKa value of the cationic lipid used. LNPs formed with DLin-MC3-DMA with a pKa of 6.2 to 6.5 exhibit higher gene-silencing activity.

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If you have any questions, please don't hesitate to contact us. We're always here to help with Pharmaceutical Excipients for your business. We can provide products ranging from grams to tons. AVT is able to produce and even register the product in US FDA according to your special needs.

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