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The high-purity cholesterol (CHO-HP) supplied by V.A.T. is suitable for the preparation of fat emulsions and liposomes. Compared to its role as an emulsifier in fat emulsions, CHO is more widely used in liposome preparation. It has been extensively employed as a membrane material in commercially available liposomal products and liposomal products (such as Lipoplatin, a liposomal cisplatin) at clinical stages.
| Product name | High purity cholesterol CHO-HP |
| Chemical name | Cholesterol, 5-Cholesten-3β-ol |
| Molecular formula | C27H46O |
| CAS No. | 57-88-5 |
| CDE Record registration Number | F20170000106(A) |
| FDA DMF Number | |
| Grade | injection |
| Quality standards | Conforms with USP, EP, JP, ChP standards |
| Sufficient supply, cost-effective | |
| Description | white powder |
| Applications | Liposomes, regulate phospholipid membrane fluidity |
| Product Code | O01001 |
| Available Package Sizes |
CHO can insert into the phospholipid bilayer of liposomes, interacting with phospholipid molecules to modulate the fluidity of the liposome membrane. Its effect varies with temperature changes;
As CHO is amphiphilic, possessing both hydrophilic and hydrophobic properties, it can enhance the stability of liposomes by regulating the liposome membrane.
Cholesterol, also known as cholestane, is a cyclopentane polyhydrophenanthrene derivative. At temperatures above the phase transition temperature, CHO reduces the mobility of phospholipid fatty acid chains, thereby decreasing the fluidity of phospholipid molecules. Conversely, at temperatures below the phase transition temperature, it prevents the interaction between phospholipid fatty acid chains, thereby preventing a significant decrease in the fluidity.
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