AVT (Shanghai) Pharmaceutical Tech Co., Ltd.


As a commonly used helper lipid, DOPE exhibits strong synergistic effects in the preparation of cationic liposomes. Liposomes formulated with DOPE have been developed into commercial transfection reagents and are widely used in basic research. Additionally, DOPE is also an essential helper lipid in cationic lipid formulations and marketed liposomal vaccines such as Epaxal and Inflexal V.

Product Description

Product name1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine(DOPE)
Chemical name
Molecular formulaC41H78NO8P
CAS No.768593
CDE Record registration Number
FDA DMF Number
Quality standards

Sufficient supply, cost-effective
Descriptionwhite to off-white waxy solid
ApplicationsLiposomes, lipid nanoparticles, regulate phospholipid membrane fluidity
Product CodeO03005
Available Package Sizes

Key Benefits of DOPE

DOPE is the most commonly used helper lipid. Liposomes prepared using DOPE demonstrate better fusogenicity and transfection efficiency compared to those prepared using DOPC or CHO. DOPE can facilitate self-assembly and endosomal escape of liposomes. When combined with cationic lipids, DOPE can enhance the transfection efficiency of naked siRNA.

DOPE Product Properties

DOPE is a phosphatidylethanolamine with two unsaturated chains (C18). The unsaturated tails facilitate the formation of more fluid lipid bilayers and can also adopt a hexagonal (HII) phase. The HII phase aids in promoting fusion between lipid bilayers and intracellular membranes, facilitating the release of nucleic acids into the cytoplasm.

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