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As a commonly used helper lipid, DOPE exhibits strong synergistic effects in the preparation of cationic liposomes. Liposomes formulated with DOPE have been developed into commercial transfection reagents and are widely used in basic research. Additionally, DOPE is also an essential helper lipid in cationic lipid formulations and marketed liposomal vaccines such as Epaxal and Inflexal V.
| Product name | 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine(DOPE) |
| Chemical name | |
| Molecular formula | C41H78NO8P |
| CAS No. | 768593 |
| CDE Record registration Number | |
| FDA DMF Number | |
| Grade | injection |
| Quality standards | |
| Sufficient supply, cost-effective | |
| Description | white to off-white waxy solid |
| Applications | Liposomes, lipid nanoparticles, regulate phospholipid membrane fluidity |
| Product Code | O03005 |
| Available Package Sizes |
DOPE is the most commonly used helper lipid. Liposomes prepared using DOPE demonstrate better fusogenicity and transfection efficiency compared to those prepared using DOPC or CHO. DOPE can facilitate self-assembly and endosomal escape of liposomes. When combined with cationic lipids, DOPE can enhance the transfection efficiency of naked siRNA.
DOPE is a phosphatidylethanolamine with two unsaturated chains (C18). The unsaturated tails facilitate the formation of more fluid lipid bilayers and can also adopt a hexagonal (HII) phase. The HII phase aids in promoting fusion between lipid bilayers and intracellular membranes, facilitating the release of nucleic acids into the cytoplasm.
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