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C12-200 is an ionizable cationic lipid and helper lipid. Its cationic properties enable it to effectively bind with negatively charged nucleic acids (such as mRNA), thus facilitating intracellular nucleic acid delivery. Research has proposed a method for preparing freeze-dried C12-200vmRNA LNPs utilizing a continuous freeze-drying technique based on spin-freezing.
| Product name | C12-200 |
| Chemical name | 1-[2-[Bis(2-hydroxydodecyl) amino] ethyl-[2-[4-[2-[bis(2-hydroxydodecyl) amino] ethyl] piperazin-1-yl] ethyl] amino] dodecan-2-ol |
| Molecular formula | C70H145N5O5 |
| CAS No. | 1220890-25-4 |
| CDE Record registration Number | |
| FDA DMF Number | |
| Grade | injection |
| Quality standards | |
| Sufficient supply, cost-effective | |
| Description | Colorless to pale yellow (viscous liquid) |
| Applications | It can be used in combination with other lipids to form lipid nanoparticles (LNPs) by self-assembly for delivery of messenger RNA (mRNA), small interfering RNA (siRNA) or self-amplifying RNA (saRNA). |
| Product Code | E01003 |
| Available Package Sizes |
C12-200 can effectively deliver siRNA in vivo and achieve efficient gene silencing effects at low doses.
C12-200 is a multi-tail and branched-chain ionizable lipid with five hydroxyl groups. Its structure allows it to form more cone-like structures within cells, thereby enhancing its intracellular efficacy, particularly its ability to disrupt endosomes.
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