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DMG-PEG 2000 is a novel long-circulating lipid material that can be used for preparing liposomes for siRNA transfection, enhancing transfection efficiency. It can also be employed in preparing lipid nanoparticles (LNPs) for the oral delivery of plasmid DNA in vivo, improving the mucosal permeability and delivery efficiency of LNPs.
| Product name | 1,2-Dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000(DMG-PEG2000) |
| Chemical name | |
| Molecular formula | C32H62O5 (C2H4O) n, n ≈ 45 |
| CAS No. | 160743-62-4 |
| CDE Record registration Number | F20210000451 |
| FDA DMF Number | |
| Grade | injection |
| Quality standards | |
| Sufficient supply, cost-effective | |
| Description | white to off-white solid |
| Applications | Long circulating liposomes, Moderna COVID-19 vaccine |
| Product Code | O02005 |
| Available Package Sizes |
Liposome-based nucleic acid drugs utilizing DMG-PEG 2000 demonstrate a quicker dissociation in vivo compared to other long-circulating phospholipids like DSPE-PEG 2000, with a half-life of less than 30 minutes. This facilitates simultaneous enhancement of liver targeting and gene silencing efficiency, achieving better therapeutic efficacy through in vivo long circulation and passive targeting.
DMG-PEG 2000 is a fully synthetic PEGylated short-chain lipid. Its C14 chain is much shorter than the C18 chain of DSPE-mPEG 2000. Its shorter chain allows for rapid dissociation while achieving in vivo escape, countering the failure of "endosomal escape" caused by PEGylation.
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