AVT (Shanghai) Pharmaceutical Tech Co., Ltd.
dmg peg2000


DMG-PEG 2000 is a novel long-circulating lipid material that can be used for preparing liposomes for siRNA transfection, enhancing transfection efficiency. It can also be employed in preparing lipid nanoparticles (LNPs) for the oral delivery of plasmid DNA in vivo, improving the mucosal permeability and delivery efficiency of LNPs.

Product Description

Product name1,2-Dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000(DMG-PEG2000)
Chemical name
Molecular formulaC32H62O5 (C2H4O) n, n ≈ 45
CAS No.160743-62-4
CDE Record registration NumberF20210000451
FDA DMF Number
Quality standards

Sufficient supply, cost-effective
Descriptionwhite to off-white solid
ApplicationsLong circulating liposomes, Moderna COVID-19 vaccine
Product CodeO02005
Available Package Sizes

Key Benefits of DMG-PEG2000

Liposome-based nucleic acid drugs utilizing DMG-PEG 2000 demonstrate a quicker dissociation in vivo compared to other long-circulating phospholipids like DSPE-PEG 2000, with a half-life of less than 30 minutes. This facilitates simultaneous enhancement of liver targeting and gene silencing efficiency, achieving better therapeutic efficacy through in vivo long circulation and passive targeting.

DMG-PEG2000 Product Properties

DMG-PEG 2000 is a fully synthetic PEGylated short-chain lipid. Its C14 chain is much shorter than the C18 chain of DSPE-mPEG 2000. Its shorter chain allows for rapid dissociation while achieving in vivo escape, countering the failure of "endosomal escape" caused by PEGylation.

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